Anti-TAp63 Purified

The p53 family of proteins includes three members, p53, p63, and p73. The protein p63 is encoded by TP63 gene, which gives rise to protein isoforms with different properties and functions due to the presence (TAp63) or absence (deltaNp63) of an N-terminal transactivation domain. Immunohistochemistry of p63 has a clinical relevance for certain tumor types, but investigations have been hampered by a lack of well characterized antibodies that are specific for p63, do not cross-react with the related p53 and p73 proteins, and allow for discrimination between p63 isoforms TAp63 and deltaNp63 with opposite functional properties.

The mouse monoclonal antibody TAp63-4.1 recognizes TAp63 target epitope LSDPMW. This antibody does not bind to deltaNp63 isoform of p63.

RUO

Mouse

Mouse, Rat, Human

Recombinant human p63

TAp63

IgG2a

TAp63-4.1

Western blotting: Recommended dilution: 1 μg/mL

WB, IHC-P, ICC, IP

1 mg/mL

Purified

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

*Nekulová M, Holčáková J, Nenutil R, Stratmann R, Bouchalová P, Müller P, Mouková L, Coates PJ, Vojtěšek B: Characterization of specific p63 and p63-N-terminal isoform antibodies and their application for immunohistochemistry. Virchows Arch. 2013 Sep463(3):415-25., URL: https://pubmed.ncbi.nlm.nih.gov/23887585/,

Store at 2-8°C. Do not freeze.