Secondary Antibody

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AFX encodes a member of the specific class of transcription factor family. Proteins are controlled by factors involved in growth and differentiation, signaling they play a part in these processes. A translocation between this particular gene on chromosome X and the homolog encoding a DNA binding protein is connected with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.

F7: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates. Factor VII is converted to factor VIIa by proteolysis by factor XIIa, factor Xa, factor IXa, or thrombin. At the presence of calcium ions and tissue factor, factor VIIa subsequently converts factor X to factor Xa by limited proteolysis. Factor VIIa will convert factor IX to factor IXa in the presence of calcium and tissue factor. Defects in F7 are the cause of factor VII deficiency (FA7D). A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, by comparison, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked with a surgical intervention. Finally, numerous subjects are asymptomatic despite low factor VII levels. Alternative splicing produces Two isoforms of the human protein.

The protein encoded by NTCP gene belongs to the sodium/bile acid cotransporter family, and that are. 2 homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter having an apical cell localization that absorbs bile acids in the intestinal lumen, bile liver and liver, and also the liver-specific sodium/bile acid cotransporter, represented by this protein, which are located from the basolateral membranes of hepatocytes. Acids are the product of cholesterol metabolism that protein is essential for cholesterol homeostasis.

AMPylation is a reversible post-translational alteration where adenosine monophosphate (AMP) derived from ATP is added to threonine and tyrosine (and maybe serine) residues on target proteins. This modification is produced by proteins comprising Fic (filamentation induced by cyclic adenosine monophosphate) domain names, which are found in both prokaryotic and eukaryotic cells. The HYPE protein is the protein that is most commonly known along with its own AMPylated targets’ purpose isn’t yet very clear. But cells have numerous proteins which disable and change protein goals increasing the robustness of infections and thus controlling signaling pathways. The Vibrio parahaemolyticus VopS protein, for example, interrupts the role of Rho guanine triphosphatases and disrupts the actin cytoskeleton.

Localized angiopoietin-2 (Ang2) expression was demonstrated to be a crucial regulator of blood vessel remodeling and tumor angiogenesis, which makes it an appealing candidate for antiangiogenic treatment. A fully human monoclonal antibody (3.19.3) has been designed, which could have significant pharmaceutical benefits over synthetic peptide-based approaches with regard to decreased immunogenicity and enhanced half-life to obstruct Ang2 function. The 3.19.3 antibody potently contrasts Ang2 having an equilibrium dissociation constant of 86 pmol/L, resulting in inhibition of Tie2 receptor phosphorylation in cell-based assays.

COMM domain containing 5 COMMD5 (synonyms: HCARG, HT002) is a hypertension-related calcium-regulated gene. Extracellular calcium concentration negatively regulates cOMMD5, and its mRNA levels were greater. Tissue distribution of COMMD5 indicates a preponderance at the center, stomach, jejunum, kidney (tubular fraction), liver, and adrenal gland (mostly from the medulla). COMMD5 mRNA is widespread in mature than in organs, and its levels are diminished in cell lines and tumors. COMMD5 protein has no transmembrane domain but comprises 67 percent -helix content, a calcium-binding website, four putative”leucine zipper” themes, and also a nuclear receptor-binding domainname. At the subcellular level, COMMD5 reveals nuclear localization.

Cullin-4 (CUL4) is a part of the cullin family of associated ubiquitin ligases. A set of otherworldly CUL4 proteins – CUL4B and CUL4A – continues to be identified. The domain name of CUL4 interacts with Rbx1 and E2 enzyme, while the CUL4 domain interacts with BPB domain name of DNA binding protein DDB1 to make a CUL4-DDB1 ubiquitin. This CUL4-DDB1 complex binds an assortment of WD40-containing proteins which help enhance substrate recruitment that is extra. The CUL4 complex was demonstrated to target substrates involved in growth, cell cycle progression, transcription, as well as DNA repair.

IL-23R is a 629 aa, a novel subunit of the receptor for the cytokine IL23A/IL23 which matches together with the receptor molecule beta 1and take part. Signal transduction analysis affirms this particular protein associates constitutively with Janus kinase 2 (JAK2) and binds to transcription activator STAT3 at a ligand-dependent method. Alternative splicing contributes to six spliced isoforms of IL-23R. Reports indicate that IL-23R it’s a possible therapeutic target in inflammatory bowel disease and has a significant function.

IL-23R is a 629 aa, a novel subunit of the receptor for the cytokine IL23A/IL23 which matches together with the receptor molecule beta 1and take part. Signal transduction analysis affirms this particular protein associates constitutively with Janus kinase 2 (JAK2) and binds to transcription activator STAT3 at a ligand-dependent method. Alternative splicing contributes to six spliced isoforms of IL-23R. Reports indicate that IL-23R it’s a possible therapeutic target in inflammatory bowel disease and has a significant function.

GM130: Golgi auto-antigen construction that is involved in preserving cis-Golgi. Part of a larger complex that is oligomeric. Interacts. Interacts with ZFPL1 and GORASP1/GRASP65. Belongs to the household that is GOLGA2. Alternative splicing produces Two isoforms of the anatomy.

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