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Antibody for Human ROR2 (pTyr645 + pTyr646)

Supplier Stressmarq · Catalog number: SPC-1075D-A565
Price

528 USD

Size
0.1ml

A polyclonal antibody for ROR2 (pTyr645 + pTyr646) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Tyr645 and Tyr646 of human ROR2 (AA642-649). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ROR2 (pTyr645 + pTyr646) antibody is conjugated to ATTO 565.

  • Additional information:ROR2 is a receptor tyrosine kinase which may have a role in early cartilage and growth plate development. ROR2 expression is generally highest during embryonic development and will gradually decrease as cells terminally differentiate. Wnt5a has been identified to utilize ROR2 as a co-receptor for non-canonical Wnt signalling. Aberrant expression of ROR2 has been implicated in gastric, osteosarcoma, mestatic melanoma, prostate, renal cell and squamous cell carcinomas. Increased expression of ROR2 was correlated with increased metastasis. In prostate, osteosarcomas and metastatic melanomas, Wnt5a/ROR2 receptor complex formation was implicated as the mechanism for cancer progression. ROR2 seems to function as an oncogene. Primarily mis-sense mutations of ROR2 have been identified in tumours but their functional effect has not been well characterized.
  • Storage and shipping:
    • Shipped on ice packs at +4ºC. Upon receipt keep at -20ºC.
    • The gross weight ( in kg) of the package is ~1.4 kg. The net weight of the product is ~0.1 grams.
    • The item is not hazardous according to both ADR and UN. Its tariff code is 3002.15.0000 (Immunological products, put up in measured doses or in forms or packings for retail sale). The UNSPSC code of the product is 12352203 (Antibodies).
  • Notes:This product is not for human or animal treatment or consumption. Not for use in diagnostics or therapeutics. For in vitro research use only.

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