Quantitative sandwich ELISA for measuring Bovine Pentraxin-related protein PTX3 (PTX3) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

• Additional information:
  
  • Pentraxin-related protein PTX3 also known as TNF-inducible gene 14 protein (TSG-14) is a protein that in humans is encoded by the PTX3 gene.Pentraxin 3 (ptx3) is a member of the pentraxin superfamily. This super family characterized by cyclic multimeric structure. PTX3 is rapidly produced and released by several cell types, in particular by mononuclear phagocytes, dendritic cells (DCs), fibroblasts and endothelial cells in response to primary inflammatory signals [e.g., toll-like receptor (TLR) engagement, TNF?, IL-1?]. PTX3 binds with high affinity to the complement component C1q, the extracellular matrix component TNF? induced protein 6 (TNFAIP6
  • also called TNF-stimulated gene 6, TSG-6) and selected microorganisms, including Aspergillus fumigatus and Pseudomonas aeruginosa PTX3 activates the classical pathway of complement activation and facilitates pathogen recognition by macrophages and DCs.
• Storage and shipping:All of the components are shipped on ice packs/blue ice. Upon receiving the kit keep it at +4 degrees Celsius for up to 1 year (refer to the label on the box for the exact expiration date).
• Notes:This kit is intended for research use only. It should not be used for human or animal clinical diagnostics or treatment.