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Human R-spondin-2 (RSPO2) ELISA Kit

Supplier Abbkine · Catalog number: KTE60782-96T
Price

648 USD

Size
96T

This Human R-spondin-2 (RSPO2) ELISA Kit employs a two-site sandwich ELISA to quantitate RSPO2.

  • Additional information:R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1) signaling. Xenopus and human RSPO2 enhanced mouse Wnt3a signaling in transfected human embryonic kidney cells. C-terminally truncated Xenopus Rspo2, but not the full-length protein, was secreted from cells and retained its activity. Mutation analysis showed that the TSP1 domain of Xenopus Rspo2 was dispensable for activity, but the furin domains were required. RT-PCR analysis showed that Xenopus embryos injected with Wnt8 or beta-catenin induced Rspo2 and Rspo3. Overexpression of Rspo2 in Xenopus activated the Wnt/beta-catenin pathway upstream of dishevelled (DVL1), interfered with Tgfb-type growth factors, and promoted myogenesis.
  • Storage and shipping:Storage: The unopened kit should be stored at 2 - 8°C. After opening, please store refer to protocols.Shipping:Gel pack with blue ice.
  • Notes:This kit is intended for research use only. It should not be used for human or animal clinical diagnostics or treatment.

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