The PTEN-induced putative kinase 1 (PINK1) is a serine/threonine protein kinase that localizes to mitochondria and is thought to protect cells from stress-induced mitochondrial dysfunction (reviewed in 1). PINK1 recruits the E3 ubiquitin ligase Parkin to mitochondria to initiate mitophagy, an autophagic process that clears damaged mitochondria within a cell (2). PINK1 is cleaved by the mitochondrial protease PARL (3). Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease (4).

• Additional information:Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
• Storage and shipping:
  
  • PINK1 antibody can be stored at 4˚
  • C for three months and -20˚
  • C, stable for up to one year.
• Notes:Optimal dilutions for each application to be determined by the researcher.