The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.

• Additional information:In 1X PBS, pH 7.4, with 0.09% sodium azide
• Storage and shipping:Aliquot the RIPK3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.