Anti-p63 Purified

The p53 family of proteins includes three members, p53, p63, and p73. The protein p63 is encoded by TP63 gene, which gives rise to protein isoforms with different properties and functions due to the presence (TAp63) or absence (deltaNp63) of an N-terminal transactivation domain. Immunohistochemistry of p63 has a clinical relevance for certain tumor types, but investigations have been hampered by a lack of well characterized antibodies that are specific for p63 and do not cross-react with the related p53 and p73 proteins.

The mouse monoclonal antibody PANp63-6.1 recognizes both TAp63, and deltaNp63 form of p63. The target epitope PSHLIR is located within amino acids 261-266 of TAp63, and 167-172 of deltaNp63.

RUO

Mouse

Mouse, Rat, Human

Recombinant full length human p63

p63

IgG1

PANp63-6.1

Western blotting: Recommended dilution: 1 μg/mL

WB, IHC-P, ICC, IP

1 mg/mL

Purified

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

*Nekulová M, Holčáková J, Nenutil R, Stratmann R, Bouchalová P, Müller P, Mouková L, Coates PJ, Vojtěšek B: Characterization of specific p63 and p63-N-terminal isoform antibodies and their application for immunohistochemistry. Virchows Arch. 2013 Sep463(3):415-25., URL: https://pubmed.ncbi.nlm.nih.gov/23887585/,

Store at 2-8°C. Do not freeze.