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AMG-1694

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AMG-1694

Product Description:

AMG-1694

Specifications:

Purity: 0.98

CAS#: 1361217-07-3

Molecular Weight: 533.63

Bioactivity: AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1]. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation.

Additional informations:

SMILES: C([C@@H]1N(CCN(S(=O)(=O)C2=CC=CS2)C1)C3=CC=C([C@@](C(F)(F)F)(C)O)C=C3)N4[C@@H](C)COCC4

Formula: C23H30F3N3O4S2

Notes:

For research use only.