Recognizes a 67kDa transmembrane protein, which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms. Anti-CD5 detection is diagnostic in CLL/SLL within a panel of other B-cell markers, especially one that includes anti-CD23. Anti-CD5 is also very useful in differentiating among mature small lymphoid cell malignancies. In addition, anti-CD5 can be used in distinguishing thymic carcinoma (+) from thymoma (-). Anti-CD5 does not react with granulocytes or monocytes.

P06127

A portion of amino acids 450-495 from the human protein was used as the immunogen for this antibody.

IHC-P

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Store the CD5 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This CD5 antibody is available for research use only.

https://www.nsjbio.com/get_image.php?catalog_no=V3120-100UG&type=image1

https://www.nsjbio.com/tds-pdf/cd5-antibody-cd5-54-f6-v3120