It recognizes a protein of 120kDa, which is identified as Cadherin 17 (also known as LI Cadherin). The cadherins are a family of Calcium-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including beta-catenin, to regulate cadherin function. LI-cadherin (for liver-intestine-cadherin) expression is restricted to liver and intestine tissues and is specifically localized to the basolateral domain of hepatocytes and enterocytes.

Q12864

A recombinant partial protein sequence (within amino acids 242-418) from the human protein was used as the immunogen for the LI Cadherin antibody.

Recombinant

IHC-P

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Aliquot the LI Cadherin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This LI Cadherin antibody is available for research use only.

http://www.nsjbio.com/get_image.php?catalog_no=V5219-100UG&type=image1

http://www.nsjbio.com/tds-pdf/li-cadherin-antibody-cadherin-17-rcdh17-8514-v5219