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Anti-MSH6 (DNA Mismatch Repair Protein)(MSH6/3089), Biotin conjugate

Name: Anti-MSH6 (DNA Mismatch Repair Protein)(MSH6/3089), Biotin conjugate
Brand: Genprice
SKU: BNCB3089-100
Price: 999 USD

CAT:BNCB3089-100Size:100 µLPrice:Ask for quotation

Availability:

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Shipping:

This product ships without dry ice.

Anti-MSH6 (DNA Mismatch Repair Protein)(MSH6/3089), Biotin conjugate

Description:

The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Synonyms:

DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; GTMBP; hMSH6; HNPCC5; HSAP; MSH6; mutS (E. coli) homolog 6; MutS alpha 160kDa subunit; MutS-alpha 160kDa subunit; p160; Sperm associated protein

UNSPSC:

41116161

UNSPSC Description:

Primary and secondary antibodies for multiple methodology
immunostaining detection application

Gene Name:

MSH6

Gene ID:

2956

NCBI Gene ID:

445052

UniProt:

P52701

Cellular Locus:

Nucleus

Immunogen:

Recombinant fragment of human MSH6 protein (around aa 374-540) (exact sequence is proprietary)

Target Antigen:

MSH6

Clone:

MSH6/3089

Conjugation:

Biotin

Source:

Animal

Applications:

IHC, FFPE (verified) | WB (verified)

Positive Control:

HCT116, A431 or HeLa cells. Human colon carcinoma (IHC).

Concentration:

0.1 mg/mL

Buffer:

PBS, 0.1% BSA, 0.05% azide

Molecular Weight:

163 kDa

Shipping Conditions:

Room temperature

Storage Conditions:

4°C; Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life:

2 years

Product Picture:

https://biotium.com/wp-content/uploads/2021/02/view_image-591.jpeg

Product Datasheet:

https://cdn.gentaur.com/products/extension/v_datasheet/PI-Protocols-for-Antibody-Based-Detection.pdf

Product MSDS:

https://cdn.gentaur.com/products/extension/v_msds/SDS-primary-antibodies.pdf

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