CHD8 rabbit pAb

This gene encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. It binds beta-catenin and negatively regulates Wnt signaling pathway, which plays a pivotal role in vertebrate early development and morphogenesis. Mice lacking this gene exhibit early embryonic death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010],

57680

Q9HCK8

Nucleus. Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites..

Rabbit

Human, Rat, Mouse,

Synthesized peptide derived from part region of human protein

Polyclonal

IHC, IF

1 year

1 mg/mL

IHC-p 1:50-300

283kD

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.