FIG4 rabbit pAb

The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008],

Polyphosphoinositide phosphatase (EC 3.1.3.-) (Phosphatidylinositol 3, 5-bisphosphate 5-phosphatase) (SAC domain-containing protein 3)

9896

Q92562

Endosome membrane. Localization requires VAC14 and PIKFYVE..

Rabbit

Human,Mouse

Synthesized peptide derived from human FIG4. at AA range: 341-390

Polyclonal

WB,ELISA

1 year

1 mg/mL

WB 1:500-2000, ELISA 1:10000-20000

110kD

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.