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HAP1 Antibody

Supplier ProSci · Catalog number: 4205-002mg
Price

227 USD

Size
0.02 mg

HAP1 Antibody: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.

  • Additional information:Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
  • Storage and shipping:
    • HAP1 antibody can be stored at 4˚
    • C for three months and -20˚
    • C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Notes:Optimal dilutions for each application to be determined by the researcher.

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