Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

• Additional information:In 1X PBS, pH 7.4, with 0.09% sodium azide
• Storage and shipping:Aliquot the Histone H3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.