IRAK Detection Set

Supplier ProSci · Catalog number: PSI-1802

973 USD

1 Set

Members of the IRAK (IL-1R-associated kinase)/Pelle family play a major role in IL-1R/TLR mediated inflammatory responses and in innate immunity. IRAK and IRAK-2 regulate the activity of a signaling cascade that mediates the activation of NF-κB and MAP kinase. IRAK-4 interacts with and phosphorylates IRAK, while IRAK-M is thought to inhibit the recruitment and activation of IRAK-4 and IRAK. The importance of the IRAK family in inflammation and immunity is illustrated by the fact that animals lacking IRAK-4 are impaired in their responses to viral and bacterial challenges and are completely resistant to LPS challenge.;;For images please see PDF data sheet

  • Additional information:Optimal dilutions for each application to be determined by the researcher.
  • Storage and shipping:
    • Stable at 4°C for three months, store at -20°C for up to one year.
    • Shipping Condition: Not Specified
  • Notes:For Research Use Only

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