Genprice

MAML2 Antibody

Supplier NSJ Bioreagents · Catalog number: V7236SAF-100UG
Price

467 USD

Size
100 ug

Mastermind-like 2, also known as MAM2, MAM3 or MLLMAML2, is a nuclear speckle protein that acts as a transcriptional co-activator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML2 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, it interacts with the ankyrin repeats of the Notch proteins (1-4). This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jκ; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML2 is essential for proper Notch binding, the C-terminal domain of MAML2 is essential for transcriptional activation. A chromosomal aberration involving the gene is implicated in mucoepidermoid carcinomas, clear cell hidradenomas and benign Warthin tumors.

  • Additional information:
    • 1 mg/ml in 1X PBS
    • BSA free, sodium azide free
  • Storage and shipping:Store the MAML2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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