PEK/PERK rabbit pAb

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015],

Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK)

9451

Q9NZJ5

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Rabbit

Human, Mouse, Rat

Synthesized peptide derived from human PEK/PERK Polyclonal

Polyclonal

WB, ELISA

1 year

1 mg/mL

WB 1:500-2000, ELISA 1:10000-20000

130kD

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.