RIPK1 Antibody

Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.

Q13546

Rabbit

A portion of amino acids 152-180 from the human protein was used as the immunogen for this RIPK1 antibody.

Polyclonal

Ig

WB, IHC, ELISA

Antigen affinity purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the RIPK1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This RIPK1 antibody is available for research use only.

Primary antibody

https://www.nsjbio.com/tds/ripk1-antibody-f43338