PIP4K2 alpha Antibody / PIP4K2A

Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin- stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.

P48426

Rabbit

A portion of amino acids 329-363 from the human protein was used as the immunogen for the PIP4K2 alpha antibody.

Polyclonal

Ig

FACS, IHC-P, WB, IF

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the PIP4K2 alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This PIP4K2 alpha antibody is available for research use only.