Anti-Ms CD2 PE

CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.

The rat monoclonal antibody RM2-5 recognizes an extracellular epitope of CD2, a 50 kDa glycoprotein present on the human peripheral blood T lymphocytes and NK cells also expressed by all thymocytes.

RUO

Rat

Mouse

murine thymocytes

CD2

IgG2b λ

RM2-5

FC

0.5 mg/mL

PE

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

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Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.