Integrin alpha 7 Antibody / ITGA7

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.

Q13683

Rabbit

A portion of amino acids 247-279 from the human protein was used as the immunogen for the Integrin alpha 7 antibody.

Polyclonal

Ig

WB, FACS, IHC-P, IF

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the Integrin alpha 7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Integrin alpha 7 antibody is available for research use only.