E Cadherin Antibody

CDH1 is a classical cadherin from the cadherin superfamily. This protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization.

P12830

Rabbit

A portion of amino acids 160-189 from the human protein was used as the immunogen for this E Cadherin antibody.

Polyclonal

Ig

WB, FACS, ELISA

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the E Cadherin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This E Cadherin antibody is available for research use only.