Parathyroid Hormone Antibody Cocktail / N + C Terminal

PTH is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

P01270

Mouse

Synthetic peptides corresponding to amino acids 1 to 34 (clone 3H9) and 32-115 (clone PTH/1175) were used as the immunogen for the PTH antibody cocktail.

Monoclonal

IgG2b κ

IHC-P

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Store the PTH antibody cocktail at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This PTH antibody cocktail is available for research use only.