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VTCN1 Recombinant Antibody / B7H4
T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.
Q7Z7D3
Rabbit
A recombinant human partial protein was used as the immunogen for this recombinant B7-H4 antibody.
Monoclonal
IgG κ
Recombinant
IHC-P
Purified
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Store the recombinant B7-H4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
This recombinant B7-H4 antibody is available for research use only.
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