Caspase-3 Antibody

CASP3 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.

P42574

Rabbit

A portion of amino acids 60-90 from the human protein was used as the immunogen for this anti-Caspase-3 antibody.

Polyclonal

Ig

WB, FACS, IHC, ELISA

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the anti-Caspase-3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This anti-Caspase-3 antibody is available for research use only.