Lamin A/C Antibody

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone.

P02545

Rabbit

This Lamin A/C antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 465-498 amino acids from the Central region of the human protein.

Polyclonal

Ig

WB, ELISA

Antigen affinity purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the Lamin A/C antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Lamin A/C antibody is available for research use only.