Perforin Antibody / PRF1

Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8+ T-cells, natural killer cells and some CD4+ T-cells.

P14222

Mouse

A recombinant human partial protein (amino acids 413-552) was used as the immunogen for this Perforin-1 antibody.

Monoclonal

IgG2b κ

ELISA

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Store the Perforin-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This Perforin-1 antibody is available for research use only.