Caspase-3 Antibody

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

P42574

Mouse

Purified His-tagged protein was used to produced this monoclonal Caspase-3 antibody.

Monoclonal

IgG1

WB, ELISA

Purified

In 1X PBS pH 7.4 with 0.09% sodium azide

Aliquot the Caspase-3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Caspase-3 antibody is available for research use only.