Androgen Receptor Antibody Cocktail

Recognizes a protein of 100kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin. This mAb is superb for staining of formalin/paraffin tissues.

P10275

Mouse

Amino acids 302-318 (STEDTAEYSPFKGGYTK) of human AR (AR441) and recombinant human AR partial protein (aa 151-350, DHTR/882) were used as the immunogen for the Androgen Receptor antibody cocktail.

Monoclonal

IgG1 κ

IHC-P

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Store the Androgen Receptor antibody cocktail at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This Androgen Receptor antibody cocktail is available for research use only.