Blood Group Lewis a Antibody

Recognizes a carbohydrate determinant of Gal 1-3(Fuc 1-4) GlcNAc which is blood group antigen Lewis A. It is present primarily on epithelial cells such as colon and kidneys. In the tumors and dedifferentiated tissues, decrease of Lewis A antigen was observed. Lewis A (type 1 chain) is expressed in colonic epithelial cells and may be useful for detection of gastrointestinal tumors, pancreatic cancer, and colorectal tumors. Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids and glycoproteins. They are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group of antigens, including A, B, H, Lewis A, Lewis B, Lewis X, Lewis Y, and precursor type 1 chain antigens.

Not Applicable

Mouse

Mucins isolated from ovarian cyst fluid were used as the immunogen for the Blood Group Lewis a antibody.

Monoclonal

IgG1 κ

IHC-P

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Store the Blood Group Lewis a antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This Blood Group Lewis a antibody is available for research use only.