CD11b Antibody / MAC-1

CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin alpha-M (CD11b) combines with the Integrin beta-2 (CD18) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin alpha-M/beta-2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.

Rat

B10 mouse spleen cells enriched for T lymphocytes were used as the immunogen for this CD11b antibody.

Monoclonal

IgG2b κ

FACS, IF, Functional studies

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Store the CD11b antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This CD11b antibody is available for research use only.