Cyclin D1 Antibody / CCND1

This antibody recognizes a protein of 36kDa, identified as Cyclin D1. It is a putative proto-oncogene overexpressed in a wide variety of human neoplasms and a key cell cycle regulator. This antibody neutralizes the activity of Cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression. Cyclin D1 antibody is useful in identifying mantle cell lymphomas, which stain positive, from CLL/SLL and follicular lymphomas, which stain negative. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

Mouse

Human recombinant full length protein was used as the immunogen for this Cyclin D1 antibody.

Monoclonal

IgG2a κ

FACS, IF, WB, IHC-P

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Store the Cyclin D1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This Cyclin D1 antibody is available for research use only.