Cyclin E1 Recombinant Antibody / CCNE1

Cyclin E belongs to the highly conserved cyclin family, whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.

P24864

Mouse

A portion of amino acids 10-176 was used as the immunogen for the Cyclin E1 antibody.

Monoclonal

IgG1 κ

Recombinant

WB, IHC-P

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Aliquot the recombinant Cyclin E1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This recombinant Cyclin E1 antibody is available for research use only.