FGFR1 Antibody

FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene can lead to Pfeiffer syndrome and Jackson-Weiss syndrome. The genomic organization of the gene is very similar to family members 2-4, encompassing 19 exons that are subject to complex alternative splicing, which allows for structural, tissue expression and ligand affinity variations among the isoforms.

P11362

Rabbit

A portion of amino acids 19-48 from the human protein was used as the immunogen for this FGFR1 antibody.

Polyclonal

Ig

IHC, IF, FACS, WB, ELISA

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the FGFR1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This FGFR1 antibody is available for research use only.