Glycoprotein 2 Antibody / GP2 / ZAP75

GP2 (glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.

P55259

Mouse

A recombinant fragment of human protein (within amino acids 35-179) was used as the immunogen for the Glycoprotein 2 antibody.

Monoclonal

IgG2c κ

ELISA, WB, IHC-P

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Aliquot the Glycoprotein 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Glycoprotein 2 antibody is available for research use only.