Melanoma Associated Antigen KBA.62 Antibody

KBA.62 is a novel anti-melanoma antibody. It reacts positively against melanocytic tumors but not other tumors, thus demonstrating specificity and sensitivity. Moreover, it reacts positively against junctional nevus cells but not intradermal nevi, and against fetal melanocytes but not normal adult melanocytes. KBA.62 antibody is useful in identifying malignant melanomas. Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas, large cell lymphomas, sarcomas, spindle cell carcinomas and various types of mesenchymal neoplasms. A keratin-negative, vimentin-rich neoplasm that immuno-reacts with antibody to S-100 protein and with KBA.62 antibody is, with rare exception, a melanoma. Anti-KBA.62 is a useful additional marker for melanoma, specifically in desmoplastic/spindle cell cases and in the context of micro-metastasis in sentinel lymph node.

Not Known

Mouse

Human KAL cells derived from lymph node metastasis of malignant melanoma were used as the immunogen for the Melanoma Associated Antigen KBA.62 antibody.

Monoclonal

IgG1 κ

IF, IHC-P

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Store the Melanoma Associated Antigen KBA.62 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This Melanoma Associated Antigen KBA.62 antibody is available for research use only.