NME2 Antibody / Nucleoside diphosphate kinase B / NDKB

The nm23 gene, a potential suppressor of metastasis, was originally identified by differential hybridization between two murine melanoma sub-lines, one with a high and the second with a low metastatic capacity. Highly metastatic sub-lines exhibit much lower levels of nm23 than less metastatic cells. Based on sequence analysis, nm23 appears highly related to nucleotide diphosphate kinases (NDP). In humans, NDP kinases A and B are identical to two isotypes of human nm23 homologs, namely nm23-H1 and H2, respectively. nm23-H2 is identical in sequence to PuF, a transcription factor that binds to nuclease hypersensitive elements at positions 142 to 115 of the human c-Myc promotor.

P22392

Mouse

Recombinant full-length human protein was used as the immunogen for the Nucleoside diphosphate kinase B antibody.

Monoclonal

IgG2a κ

WB, IHC-P

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Aliquot the Nucleoside diphosphate kinase B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Nucleoside diphosphate kinase B antibody is available for research use only.