P-Glycoprotein (ABCB1) Antibody

The membrane-associated ABCB1 protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. ABCB1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

P08183

Rabbit

A portion of amino acids 647-677 from the human protein was used as the immunogen for this P-Glycoprotein antibody.

Polyclonal

Ig

WB, ELISA

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the P-Glycoprotein antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This P-Glycoprotein antibody is available for research use only.