Ribonuclease A Antibody

Ribonuclease A is an enzyme that in humans is encoded by the RNASE1 gene. By genomic sequence analysis, the gene is mapped the to chromosome 14q11.2, where it is linked to 7 other RNase superfamily genes. Monomeric human pancreatic RNase, devoid of any biological activity other than its RNA degrading ability, was engineered into a dimeric protein with a cytotoxic action on mouse and human tumor cells, but lacking any appreciable toxicity on mouse and human normal cells. This dimeric variant of human pancreas RNase selectively sensitizes to apoptotic death cells derived from a human thyroid tumor. Because of its selectivity for tumor cells, and because of its human origin, this protein represents a potentially very attractive, novel tool for anticancer therapy.

P07998

Rabbit

An amino acid sequence from the middle region of human Ribonuclease A (NTFVHEPLVDVQNVCFQEK) was used as the immunogen for this Ribonuclease A antibody.

Polyclonal

IgG

WB

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

After reconstitution, the Ribonuclease A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

This Ribonuclease A antibody is available for research use only.