S100B Antibody

Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

P04271

Mouse

A S100B synthetic peptide was used as the immunogen for this S100 beta antibody.

Monoclonal

lgG2b

WB

Purified

Antibody in PBS with 50% Glycerol and 0.03% ProClin 300

Store the S100 beta antibody at -20oC.

This S100 beta antibody is available for research use only.