Collagen VII antibody / COL7A1

Recognizes an epitope located on collagenase digested Type VII collagen (150kDa), i.e. the non-helical carboxyl terminal region of the dimer. Binding is localized at the inferior border of the lamina densa as demonstrated by immunoelectron microscopy. Type VII is also found in the retina, where its function is unknown. It interacts with Laminin 5 and Fibronectin. Collagen VII is a stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen.

Q02388

Mouse

A recombinant full-length human Collagen VII protein was used as the immunogen for this Collagen VII antibody.

Monoclonal

IgG1 κ

ELISA, WB, FACS, IF, IHC-P

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Store the Collagen VII antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This Collagen VII antibody is available for research use only.