Integrin beta 3 Antibody / ITGB3 / CD61

Reacts with human Integrin beta 3, also called CD61. It associates with the αV-chain (CD51) to form vitronectin receptor, or with the αIIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61). The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.

P05106

Mouse

Human recombinant protein used as the immunogen for the Integrin beta 3 antibody.

Monoclonal

IgG1 κ

IHC-P

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Store the Integrin beta 3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This Integrin beta 3 antibody is available for research use only.