SDHB Recombinant Antibody / Succinate dehydrogenase B

Succinate dehydrogenase B (SDHB) is an iron-sulfur subunit of mitochondrial complex II, a key component of the citric acid cycle and the electron transport chain, a respiratory complex that catalyzes the oxidation of succinate in the mitochondrial membrane.Many cancers are generally positive for SDHB, including renal cell carcinomas and gastrointestinal stromal tumors. A subset of RCC and GIST tumors that are associated with SDH mutations, Carney-Stratakis Syndrome or Carney Triad exhibit a loss of SDHB expression.

P21912

Rabbit

A synthetic peptide corresponding to human SDHB protein was used as the immunogen for the Succinate dehydrogenase B antibody.

Monoclonal

IgG κ

Recombinant

IHC-P

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Aliquot the Succinate dehydrogenase B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Succinate dehydrogenase B antibody is available for research use only.