CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

P01732

Thymocytes followed by Sezary T cells were used as the immunogen for the CD8a antibody.

FACS

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Store the CD8a antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This CD8a antibody is available for research use only.

https://www.nsjbio.com/get_image.php?catalog_no=V8216-100UG&type=image1

https://www.nsjbio.com/tds-pdf/cd8a-antibody-ucht4-v8216