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Cyclin D1 Recombinant Antibody / CCND1

CAT:V8652SAF-100UGSize:100 µgPrice:Ask for quotation

Availability:

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Shipping:

This product ships with dry ice.

Description:

Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

UniProt:

P24385

Host:

Mouse

Immunogen:

A portion of amino acids 200-295 from the human protein was used as the immunogen for the recombinant Cyclin D1 antibody.

Clonality:

Monoclonal

Isotype:

IgG2a κ

Type:

Recombinant

Applications:

IHC-P

Format:

Purified

Buffer:

1 mg/ml in 1X PBS; BSA free, sodium azide free

Reconstitution:

Store the recombinant Cyclin D1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations:

This recombinant Cyclin D1 antibody is available for research use only.

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