Breakpoint cluster region protein Antibody / BCR

The breakpoint cluster region protein (BCR) is a protein that in humans is encoded by the BCR gene. A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

P11274

Rabbit

Recombinant human protein (amino acids D3-N264) was used as the immunogen for the Breakpoint cluster region protein antibody.

Polyclonal

IgG

WB, FACS, Direct ELISA

Purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

After reconstitution, the Breakpoint cluster region protein antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

This Breakpoint cluster region protein antibody is available for research use only.