IL18R1 Antibody / Interleukin 18 receptor alpha

Interleukin-18 (IL-18) has been identified as a molecule that induces IFN-Gamma production and enhances NK cell cytotoxicity. IL-18 receptor (IL-18R) is a type I membrane protein present in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta and heart, and absent from brain, skeletal muscle, pancreas and kidney. IL-18R is present in Hodgkin s disease cell lines, and does not bind IL-1alpha or IL-1beta. The association of IL-18 to IL-18R leads to activation of NFkB. At present two subunits of IL-18R have been characterized: IL-18RAlpha and IL-18Rbeta. IL-18Ralpha has been described as the ligand-binding chain and IL-18Rbeta as the signal-transduction chain.

Q13478

Mouse

A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the Interleukin 18 receptor alpha antibody.

Monoclonal

IgG1 κ

IHC-P

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Aliquot the Interleukin 18 receptor alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Interleukin 18 receptor alpha antibody is available for research use only.