Glutamine Synthetase Antibody / GLUL

Glutamine synthetase (Gl Syn) forms a homo-octamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation.

P15104

Mouse

A portion of amino acids 50-250 was used as the immunogen for the Glutamine Synthetase antibody.

Monoclonal

IgG2bc κ

WB, IHC-P

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Aliquot the Glutamine Synthetase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Glutamine Synthetase antibody is available for research use only.